Braun-Falco O, Ryckmanns F, Schmoeckel C, Landthaler M
Arch Dermatol Res. 1983;275(5):287-95. doi: 10.1007/BF00417199.
Five patients with pityriasis rubra pilaris (PRP) were analyzed by means of light and electron microscopy as well as by histochemistry and autoradiography. The results were compared with findings in psoriasis vulgaris. In PRP we found a moderate increase of the labeling index of epidermal cells, a highly increased labeling index of dermal infiltrating cells, and a mild spongiosis, and in the stratum granulosum, a decreased number of tonofilaments and an increased number of keratinosomes. The horny layer in PRP showed a pronounced histochemical and electron microscopical parakeratosis, even when histological parakeratosis was absent. In contrast with psoriasis vulgaris, there was no exocytosis of polymorphonuclear leucocytes into the epidermis, the papillomatosis index was normal, and there were no tortuous capillaries in the dermal papillae. The stratum granulosum was always present and sometimes thickened, showing electron microscopical changes different from those referred to in psoriasis. These changes point to a relatively distinct pattern of epidermal changes in PRP.
对5例毛发红糠疹（PRP）患者进行了光镜、电镜、组织化学及放射自显影分析。并将结果与寻常型银屑病的表现进行了比较。在PRP中，我们发现表皮细胞标记指数中度增加，真皮浸润细胞标记指数高度增加，有轻度海绵形成，颗粒层中张力细丝数量减少，角质小体数量增加。即使组织学上不存在角化不全，PRP的角质层在组织化学和电镜下也显示明显的角化不全。与寻常型银屑病不同，多形核白细胞没有向表皮内渗出现象，乳头瘤样增生指数正常，真皮乳头内没有迂曲的毛细血管。颗粒层始终存在，有时增厚，电镜下表现出与银屑病不同的变化。这些变化表明PRP中表皮变化有相对独特的模式。
