Krasnogorskiĭ I N, Indikova M G, Tsinzerling V F, Boĭkov S G
Arkh Patol. 1983;45(10):9-14.
Examinations of 143 autopsy observations of P. aeruginosa infection in children were performed. Among them, 119 patients had pneumonia, 16 affections of the alimentary tract, 8 sepsis with various localizations of the primary focus. Morphologically the affected organs presented foci of necrosis of different size with tremendous numbers of bacteria, poor leukocyte reaction, and deep circulatory disorders in the periphery. A more manifest leukocyte infiltration in foci of lesions was observed in the cases where other bacterial microflora, in addition to P. aeruginosa, was present. P. aeruginosa isolated from the organs of dead children, as a rule, belonged to immune type 1 or 2 (according to Fisher's scheme). Microbiological studies on these strains showed the most marked necrotic changes to have been caused by microbes having such factors of pathogenicity as protease and plasmocoagulase.
对143例儿童铜绿假单胞菌感染的尸检观察进行了检查。其中，119例患者患有肺炎，16例患有消化道疾病，8例患有败血症，原发灶位于不同部位。形态学上，受累器官呈现出不同大小的坏死灶，有大量细菌，白细胞反应较弱，周边循环障碍严重。在除铜绿假单胞菌外还存在其他细菌菌群的病例中，观察到病变灶中有更明显的白细胞浸润。从死亡儿童器官中分离出的铜绿假单胞菌通常属于免疫型1或2（根据费舍尔分类法）。对这些菌株的微生物学研究表明，具有蛋白酶和血浆凝固酶等致病因素的微生物引起的坏死变化最为明显。
