Rance M, Sørensen O W, Bodenhausen G, Wagner G, Ernst R R, Wüthrich K
Biochem Biophys Res Commun. 1983 Dec 16;117(2):479-85. doi: 10.1016/0006-291x(83)91225-1.
A double quantum filter is inserted into a two-dimensional correlated (COSY) 1H NMR experiment to obtain phase-sensitive spectra in which both cross peak and diagonal peak multiplets have anti-phase fine structure, and in which the cross peaks and the major contribution to the diagonal peaks have absorption lineshapes in both dimensions. The elimination of the dispersive character of the diagonal peaks in phase-sensitive, double quantum-filtered COSY spectra allows identification of cross peaks lying immediately adjacent to the diagonal, which represents a significant improvement over the conventional COSY experiment.
在二维相关（COSY）1H NMR实验中插入一个双量子滤波器，以获得相敏谱，其中交叉峰和对角峰多重峰都具有反相精细结构，并且交叉峰和对角峰的主要贡献在两个维度上都具有吸收线形。在相敏双量子滤波COSY谱中消除对角峰的色散特性，使得能够识别紧邻对角峰的交叉峰，这相对于传统的COSY实验有了显著改进。
