Tu A T, Morita M
Br J Exp Pathol. 1983 Dec;64(6):633-7.
Myotoxin a is a muscle-damaging toxin isolated from the venom of Crotalus atrox (western diamondback rattlesnake) and is composed of 42 amino acid residues. Earlier electron microscopic observation indicated that the toxin causes extensive swelling of the sarcoplasmic reticulum followed by disorganization of the sarcomers. In the present paper we describe the evidence for the attachment of peroxidase-conjugated myotoxin a to the membrane of sarcoplasmic reticulum of human muscle. It is thus suggested that the attachment of the toxin to the sarcoplasmic reticulum and the subsequent swelling are the first steps in myonecrosis induced by myotoxin a.
肌毒素a是一种从西部菱斑响尾蛇（Crotalus atrox）毒液中分离出的肌肉损伤毒素，由42个氨基酸残基组成。早期的电子显微镜观察表明，该毒素会导致肌浆网广泛肿胀，随后肌节紊乱。在本文中，我们描述了过氧化物酶结合的肌毒素a附着于人类肌肉肌浆网膜的证据。因此，有人认为毒素附着于肌浆网及随后的肿胀是肌毒素a诱导的肌肉坏死的第一步。
