Czarnecki W, Noble M I
Cardiovasc Res. 1983 Dec;17(12):735-9. doi: 10.1093/cvr/17.12.735.
The positive inotropic effect of inosine in intact dog hearts was approximately halved by beta-adrenergic blockade with sotalol. The same result was obtained in dogs with chronic denervation of the heart, in which the sympathetic nerve terminals had degenerated. Therefore part of the positive inotropic action of inosine appears to be non-adrenergic. Inosine infusion caused supersensitivity of the positive inotropic effect over a wide range of doses of adrenaline. It is postulated that inosine may act by blocking the desensitising action of cyclic AMP on the reaction between calcium ions and the contractile proteins.
索他洛尔进行β-肾上腺素能阻滞使肌苷对完整犬心脏的正性肌力作用大约减半。在心脏慢性去神经支配（交感神经末梢已退化）的犬中也得到了同样的结果。因此，肌苷的部分正性肌力作用似乎是非肾上腺素能的。输注肌苷在肾上腺素的广泛剂量范围内引起正性肌力作用超敏。据推测，肌苷可能通过阻断环磷酸腺苷对钙离子与收缩蛋白之间反应的脱敏作用来发挥作用。
