Jick H, Porter J, Rothman K J
Ann Intern Med. 1978 Jul;89(1):58-60. doi: 10.7326/0003-4819-89-1-58.
The Boston Collaborative Drug Surveillance Program obtained medical histories on 29 premenopausal women with a discharge diagnosis of stroke. Of these women, 14 were otherwise healthy with no known predisposing illnesses. Eleven of the 14 patients were taking oral contraceptives just before admission compared with seven of 56 otherwise healthy control women (13%). The relative risk estimate for stroke among oral contraceptive users compared with nonusers is 26 (lower 90% one-sided confidence bound = 7.0). Cigarette smoking was only weakly associated with stroke in this group of women.
波士顿合作药物监测项目获取了29名绝经前女性的病史，她们出院诊断为中风。在这些女性中，14名在其他方面健康，没有已知的诱发疾病。14名患者中有11名在入院前正在服用口服避孕药，而56名其他方面健康的对照女性中有7名（13%）正在服用。与未使用口服避孕药者相比，口服避孕药使用者中风的相对风险估计值为26（90%单侧置信下限=7.0）。在这组女性中，吸烟与中风的关联较弱。
