Laccourreye H, André P
Ann Otolaryngol Chir Cervicofac. 1978 Mar;95(3):149-77.
The authors study the Time of Progression of Symptoms and Signs (TPSS) before diagnosis and treatment in 733 carcinomas of the pharyngo-larynx and 233 carcinomas of the piriform fossa. They show that for a given tumour stage (lymph node: clinical and histological), the longer the TPSS, the better the vital prognosis, the better the local and lymph node prognosis (results statistically significant). By contrast, the TPSS has no influence in the development of metastases nor in the occurrence of second tumour sites. In the opinion of the authors, TPSS, based upon routine questioning is the clinical reflection of cell division and of tumours growth. The treatment of these carcinomas whould be modified in the light of the TPSS. The value of chemotherapy used before surgery and radiotherapy is discussed in carcinomas with a short TPSS, less than 3 months, these being tumours with a rapid course with a particularly unfavourable vital, local and lymphatic prognosis.
作者研究了733例咽喉癌和233例梨状窝癌在诊断和治疗前症状和体征的进展时间（TPSS）。他们表明，对于给定的肿瘤分期（淋巴结：临床和组织学），TPSS越长，生存预后越好，局部和淋巴结预后也越好（结果具有统计学意义）。相比之下，TPSS对转移的发生和第二肿瘤部位的出现没有影响。作者认为，基于常规问诊的TPSS是细胞分裂和肿瘤生长的临床反映。这些癌症的治疗应根据TPSS进行调整。对于TPSS短于3个月的癌症，即病程快速、生存、局部和淋巴预后特别不利的肿瘤，讨论了术前和放疗前使用化疗的价值。
