Haguet J F, Brasnu D, Lebas F X
Ann Otolaryngol Chir Cervicofac. 1978 Jul-Aug;95(7-8):497-507.
The study of 112 case histories of lung cancers, both primary and secondary, has allowed the authors to determine as being of 5% the incidence of primary bronchogenic carcinoma associated with treated pharyngo-laryngeal cancer. One out of three such primaries was a solitary lung opacity. Bronchogenic primaries appeared be almost as frequent as lung, pleura and mediastine secondarie. They can be diagnosed at any moment of the treatment or follow-up of pharyngo-laryngeal cancer, and appear to occur later than pulmonary metastases. Their symptoms are more "bronchopulmonary" in nature. They are more frequently associated with endolarynx and chorda carcinomas. They are possibly more frequent in cases of smaller primaries without lymph-node involvement. Solitary lung opacities should be considered as independent primaries and constitute the best candidates for efficient pulmonary treatment. Treated pharyngo-laryngeal patients should undergo regularly spaced lung roentgenograms and frequent tracheal sputum cytology.
对112例原发性和继发性肺癌病例史的研究使作者们确定，在接受过治疗的咽喉癌患者中，原发性支气管癌的发病率为5%。在这类原发性病例中，三分之一表现为肺部孤立性混浊。支气管源性原发性肿瘤的出现频率几乎与肺、胸膜和纵隔继发性肿瘤相同。它们可在咽喉癌治疗或随访的任何阶段被诊断出来，且似乎比肺转移瘤出现得更晚。其症状本质上更具“支气管肺部”特征。它们更常与喉内癌和声带癌相关。在原发性肿瘤较小且无淋巴结受累的病例中，它们可能更为常见。肺部孤立性混浊应被视为独立的原发性肿瘤，是有效肺部治疗的最佳候选对象。接受过治疗的咽喉癌患者应定期进行胸部X光检查，并频繁进行气管痰液细胞学检查。
