Ganzer U, Sendrowski P, Vosteen K H, Meyer-Breiting P
Laryngol Rhinol Otol (Stuttg). 1981 Feb;60(2):63-70.
From 379 cases of laryngeal and pharyngeal carcinomas we picked out the T3-4 NO-3 tumors and proved whether the sandwich technique or the postoperative irradiation will give the better 5 year survival rates. For supraglottic carcinomas the 5 year survival rate is 59.9% after sandwich therapy and 53.0% after post-operative irradiation. In advanced glottic and hypopharyngeal cancers the prognosis does not depend on one of the both therapeutic schedules: the 5 year survival rate is 55.5% resp. 51.3% and 10.0% resp. 8.3%. Summarizing the carcinomas of all regions of the larynx, that is without the hypopharyngeal neoplasms, we got 54.6% after sandwich and 53.2% after post-operative irradiation. The statistical calculations demonstrate that the sandwich technique will improve the prognosis of supraglottic carcinomas distinctly. Radiotherapy alone in the treatment of advanced cancers of the larynx and hypopharynx is insufficient. The survival chance however depends essentially on the preoperative established lymph nodes. In our material the 5 year survival rate has been deteriorated by more than 25% in the case of N1-3.
从379例喉癌和下咽癌患者中，我们挑选出T3 - 4 NO - 3期肿瘤患者，以验证夹心技术或术后放疗是否能带来更高的5年生存率。对于声门上癌，夹心治疗后的5年生存率为59.9%，术后放疗后的5年生存率为53.0%。在晚期声门癌和下咽癌中，预后并不取决于这两种治疗方案中的任何一种：5年生存率分别为55.5%和51.3%，以及10.0%和8.3%。总结喉部所有区域（即不包括下咽肿瘤）的癌症，夹心治疗后为54.6%，术后放疗后为53.2%。统计计算表明，夹心技术将显著改善声门上癌的预后。单纯放疗治疗晚期喉癌和下咽癌是不够的。然而，生存机会在很大程度上取决于术前确定的淋巴结情况。在我们的资料中，N1 - 3期患者的5年生存率下降了超过25%。
