Runge M, Pantlen H, Kühnau J
Herz. 1983 Dec;8(6):344-53.
In a selected group of 14 diabetic patients (seven women, seven men) with an average age of 38 years, average duration of diabetes 20 years, all with end-organ manifestations but without hypertension or previous myocardial infarct, His bundle electrography at resting conditions and during programmed electrical stimulation was carried out to determine whether diabetes mellitus, alone, affects meaningful disturbances of impulse generation and conduction. The sinus node recovery time, conduction time through the atrium, the AV-node and the His-Purkinje system as well as the effective and functional refractory periods of the atrium and AV-node were determined. At rest, all patients had normal findings. During atrial stimulation, two patients were found to have intraatrial conduction disturbances and one patient had impaired AV-nodal conduction reserve; the latter had diminished 1:1 conduction through the AV-node during atrial stimulation. In general, however, diabetes mellitus, alone, does not appear to be of clinically-relevant pathologic importance for the development of rhythm disturbances at the levels of the sinus node and/or the AV-node and His bundle system.
在一组选定的14名糖尿病患者（7名女性，7名男性）中，平均年龄38岁，糖尿病平均病程20年，所有患者均有终末器官表现，但无高血压或既往心肌梗死，在静息状态和程序电刺激期间进行希氏束电图检查，以确定糖尿病本身是否会影响有意义的冲动产生和传导障碍。测定了窦房结恢复时间、心房、房室结和希氏-浦肯野系统的传导时间，以及心房和房室结的有效不应期和功能不应期。静息时，所有患者检查结果均正常。心房刺激期间，发现2例患者存在心房内传导障碍，1例患者房室结传导储备受损；后者在心房刺激期间通过房室结的1:1传导减弱。然而，总体而言，糖尿病本身似乎对窦房结和/或房室结及希氏束系统水平的节律紊乱发展没有临床相关的病理重要性。
