Lechtenberg R, Gilman S
Ann Neurol. 1978 Apr;3(4):285-90. doi: 10.1002/ana.410030402.
The areas of cerebellar damage most commonly associated with dysarthria were sought by reviewing the clinical, radiographic, surgical, and autopsy findings in patients with nondegenerative cerebellar disease. Case histories on 162 patients with focal cerebellar lesions were reviewed. All but 15 of the patients underwent surgery, and 28 had autopsies. Thirty-one of the 122 patients with adequate descriptions of speech had dysarthria. Twenty-two of these 31 dysarthric patients had exclusively or predominantly left cerebellar hemisphere disease; 7 had right hemisphere disease; and 2 had vermal disease. Only 19 of 41 patients with exclusively or predominantly left hemisphere disease had had normal speech before surgery. Dysarthria developed in isolated cases following cerebellar resections extending into the paravermal segments of the left hemisphere. There was no correlation between the extent of vermal damage and development of abnormal speech. Cerebellar speech function was most commonly affected with damage to the superior portion of the left cerebellar hemisphere.
通过回顾非退行性小脑疾病患者的临床、影像学、手术及尸检结果，探寻与构音障碍最常相关的小脑损伤区域。对162例局灶性小脑病变患者的病历进行了回顾。除15例患者外，其余均接受了手术，28例进行了尸检。122例有充分言语描述的患者中，31例有构音障碍。这31例构音障碍患者中，22例仅患有或主要患有左侧小脑半球疾病；7例患有右侧半球疾病；2例患有蚓部疾病。41例仅患有或主要患有左侧半球疾病的患者中，术前仅有19例言语正常。小脑切除术延伸至左侧半球旁蚓部节段后，个别病例出现了构音障碍。蚓部损伤程度与异常言语的发生之间无相关性。小脑言语功能最常因左侧小脑半球上部受损而受到影响。
