Volterrani F, Feltre L, Sigurta D, Di Giuseppe M, Luciani L
Int J Radiat Oncol Biol Phys. 1983 Dec;9(12):1781-4. doi: 10.1016/0360-3016(83)90344-9.
In the years 1971-77 we have treated 250 Stage Ib patients with cancers of the cervix. One hundred twenty-three (49.2%) underwent a radical surgery, 37 had a classical Wertheim-Meigs operation, and 86 had a lymphadenectomy that was extended to the lumbar-aortic region. When feasible, all patients received postoperative radium therapy on the vaginal vault. The remaining 127 patients received a complete course of radiotherapy. This was not a randomized clinical trial. In fact surgery was preferred for patients who were younger (mean age: 49.6 years) and more physically fit, while radiotherapy was the treatment chosen for those who were older (mean age: 57.7) and generally less fit or obese. The 5 year NED survival was 89.3% in the surgical group and 90.9% in the radiotherapy group (P less than .05). Four fatal complications were observed in the surgical group (3.2%). Rate and causes of failures or complications are analyzed in detail.
1971年至1977年间，我们治疗了250例Ib期宫颈癌患者。其中123例（49.2%）接受了根治性手术，37例行经典的韦特海姆-梅格斯手术，86例行淋巴结清扫术并扩展至腰主动脉区域。在可行的情况下，所有患者均接受了阴道穹窿术后镭疗。其余127例患者接受了完整疗程的放疗。这不是一项随机临床试验。实际上，手术更适合年龄较轻（平均年龄：49.6岁）且身体状况较好的患者，而放疗则是为年龄较大（平均年龄：57.7岁）、身体状况一般较差或肥胖的患者所选择的治疗方式。手术组的5年无疾病生存（NED）率为89.3%，放疗组为90.9%（P<0.05）。手术组观察到4例致命并发症（3.2%）。对失败率和并发症的发生率及原因进行了详细分析。
