Kleine W, Stange S, Nagy D, Ladner H A
Strahlentherapie. 1982 Aug;158(8):498-503.
An investigation was conducted in order to determine the effect of combined high voltage irradiation and the sensitizing drug misonidazole (Ro-07-0582) on human gynecologic carcinomas transplanted into nu/nu mice with thymic aplasia. Two carcinomas of the endometrium, two carcinomas of the ovaries, and one carcinoma of the cervix were submitted to Co-60 irradiation with and without misonidazole. The tumor growth was compared to that of control groups. The dosage and fractionation of the high voltage irradiation (2 x 5 Gy/week, total dose 60 Gy) were adapted to clinical data. Misonidazole (1 mg/kg body weight) was administered by intraperitoneal injection 15 minutes before the irradiation. Compared with the control animals, the locally irradiated tumors showed a slower growth or even a regression. The administration of misonidazole, however, did not produce significant differences in our five cases. Some reasons for this absence of the radiosensitizing effect of misonidazole are briefly discussed.
为了确定高压辐射与敏化药物米索硝唑（Ro-07-0582）联合使用对移植到无胸腺裸鼠体内的人类妇科癌症的影响，开展了一项研究。将两例子宫内膜癌、两例卵巢癌和一例宫颈癌在有或没有米索硝唑的情况下接受钴-60辐射。将肿瘤生长情况与对照组进行比较。高压辐射的剂量和分割方式（每周2次，每次5 Gy，总剂量60 Gy）根据临床数据进行调整。在辐射前15分钟通过腹腔注射给予米索硝唑（1 mg/kg体重）。与对照动物相比，局部照射的肿瘤生长较慢，甚至出现消退。然而，在我们的5个病例中，米索硝唑的使用并未产生显著差异。简要讨论了米索硝唑缺乏放射增敏作用的一些原因。
