Kitagawa M, Sakamoto G, Nakamura T, Kasuga T, Sugano H, Nakajima T, Kuno K
Gan No Rinsho. 1983 Nov;29(14):1673-7.
A 74-year-old female with a left breast mass was admitted to the Cancer Institute Hospital and underwent mastectomy. Upon study of a frozen section, a diagnosis of breast carcinoma was made. Histopathological examination revealed a non-invasive tumor whose slightly eosinophilic rich cytoplasm was positive for PAS and Alcian-green staining and argyrophilic staining. The tumor showed medullary arrangement, partly with glandular and rosette-like structures. Electron microscopically, many dense core granules (170 +/- 30 nm in diameter) were diffusely distributed in almost all the tumor cytoplasm, they were thought to be neurosecretory granules. A diagnosis of mucocarcinoid of the breast was made. The patient experienced no dyshormonal disorder during the course of the disease and is alive and well without recurrence.
一名74岁左侧乳房有肿块的女性入住癌症研究所医院并接受了乳房切除术。术中冰冻切片检查诊断为乳腺癌。组织病理学检查显示为非浸润性肿瘤,其富含嗜酸性的细胞质对PAS、阿尔辛蓝染色及嗜银染色呈阳性。肿瘤呈髓样排列,部分具有腺管样和玫瑰花结样结构。电镜下,许多致密核心颗粒(直径170±30nm)弥漫分布于几乎整个肿瘤细胞质中,被认为是神经分泌颗粒。诊断为乳腺黏液类癌。该患者在病程中未出现激素失调,目前健在且无复发。