Giacchi R, Sebastiani M, Lungarotti F
Ital J Surg Sci. 1986;16(4):249-53.
The so-called "carcinoid" tumors of the breast are at present a difficult entity to define. Two histopathological features are used to recognize such tumors: argyrophilia and ultrastructural dense-core granules. Eight cases of "carcinoid" tumor of the breast, observed over a 5-year period, with 3.6% incidence over the total of breast cancers recorded during the same period, are reported. All patients were females with a mean age of 55.2 years. Argyrophilia was found in all tumors and dense-core granules were observed in five studied ultrastructurally. No patient had nodal or distant metastases and no carcinoid syndrome was observed. A modified radical mastectomy was performed for tumors over 2.5 cm; in case of smaller tumors the surgical treatment was quadrantectomy with axillary dissection. All patients are alive and disease-free but follow-up is short. As the so-called "carcinoid" tumors of the breast have been only recently identified, additional morphological, immunohistochemical and clinical data are required for a full understanding of their significance.
乳腺所谓的“类癌”肿瘤目前是一种难以定义的实体。有两种组织病理学特征可用于识别此类肿瘤：嗜银性和超微结构致密核心颗粒。本文报告了在5年期间观察到的8例乳腺“类癌”肿瘤，其发病率占同期记录的所有乳腺癌的3.6%。所有患者均为女性，平均年龄55.2岁。所有肿瘤均发现嗜银性，超微结构研究的5例中观察到致密核心颗粒。无患者出现淋巴结或远处转移，也未观察到类癌综合征。肿瘤直径超过2.5 cm者行改良根治性乳房切除术；肿瘤较小者手术治疗为象限切除术加腋窝清扫术。所有患者均存活且无疾病，但随访时间较短。由于乳腺所谓的“类癌”肿瘤最近才被发现，需要更多的形态学、免疫组织化学和临床数据来全面了解其意义。
