Nishimura M, Yokoyama M, Taguchi T, Kitamura Y
Lab Anim Sci. 1983 Dec;33(6):577-9.
Histopathological examinations of stomachs of insulin-dependent (NOD) and noninsulin-dependent (KK-A gamma) mice were carried out. Spontaneous erosions in the fundic area were observed in 31% of NOD and 35% of KK-A gamma mice. The morphological features of the erosions were similar to those of erosions produced by stress. Although no erosions were detected in nondiabetic C3H/Slc mice raised and maintained in the same animal room, the presence of hyperglycemia and glycosuria in NOD and KK-A gamma mice did not appear to have a direct correlation with development of erosions. NOD and KK-A gamma mice may be useful animal models for human stress ulcers.
对胰岛素依赖型（非肥胖糖尿病，NOD）和非胰岛素依赖型（KK-Aγ）小鼠的胃进行了组织病理学检查。在31%的NOD小鼠和35%的KK-Aγ小鼠的胃底部区域观察到自发性糜烂。这些糜烂的形态特征与应激引起的糜烂相似。尽管在同一动物房中饲养和维持的非糖尿病C3H/Slc小鼠未检测到糜烂，但NOD和KK-Aγ小鼠中高血糖和糖尿的存在似乎与糜烂的发生没有直接关联。NOD和KK-Aγ小鼠可能是人类应激性溃疡的有用动物模型。
