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[食管癌切除及食管重建后的长期结果]

[Long-term results following resection and esophageal reconstruction in esophageal cancer].

作者信息

Pralat U, Dragojevic D, Hetzer R, Borst H G

出版信息

Langenbecks Arch Chir. 1983;360(4):251-65. doi: 10.1007/BF01257429.

Abstract

Between 1968 and end of 1981 162 patients, aged 30 to 77 years (mean 59,9 years) underwent esophageal resection and digestive tract reconstruction for carcinoma of the esophagus and cardia. There were 102 squamous cell- and 60 adenocarcinomas which were located in 8 patients in the upper thoracic third, in 67 patients in the middle third and in 87 patients in the lower thoracic third including the cardia. Esophago-gastrostomy was performed in 138 cases whereas colon was used in 18 and jejunum in 6 cases. Overall hospital mortality was 14.8% and was reduced to 9.4% during the period from 1976 to 1981. Survival rates at two years and 5 years were 31.8% and 5.6% resp. However, for patients with seemingly "curative" resections, i.e. when the carcinoma was limited to the esophageal wall and the lymph nodes were found uninvolved, these rates were 73.2% and 23.7% resp. Follow-up studies in 103 patients revealed typical functional sequelae such as anastomotic stenosis and reflux in less than 20% of the patients. The incidence of such symptoms was higher in patients with a low subhilar anastomosis than in patients with a high supraaortic anastomosis. It is concluded that esophageal resection and reconstruction of intestinal passage for carcinoma may significantly prolong survival and may warrant a fairly acceptable quality of life. More than 70% of the investigated long-term survivors were leading a normal life also resuming an improved nutritional status.

摘要

1968年至1981年底,162例年龄在30至77岁(平均59.9岁)的患者因食管癌和贲门癌接受了食管切除术和消化道重建术。其中有102例鳞状细胞癌和60例腺癌,病变位于胸段上1/3者8例,胸段中1/3者67例,胸段下1/3包括贲门者87例。138例行食管胃吻合术,18例行结肠代食管术,6例行空肠代食管术。总的医院死亡率为14.8%,1976年至1981年期间降至9.4%。两年和五年生存率分别为31.8%和5.6%。然而,对于那些看似“根治性”切除的患者,即癌肿局限于食管壁且未发现淋巴结受累者,这两个生存率分别为73.2%和23.7%。对103例患者的随访研究显示,典型的功能后遗症如吻合口狭窄和反流的发生率不到20%。肺门下吻合的患者出现此类症状的发生率高于主动脉弓上吻合的患者。结论是,食管癌切除及肠道通道重建可显著延长生存期,并可保证相当可接受的生活质量。超过70%的被调查长期存活者过着正常生活,营养状况也有所改善。

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