Abramov L A, Yust I C, Fierstater E M, Vardinon N E
Arch Intern Med. 1978 Jul;138(7):1156-8.
Severe respiratory distress developed in a patient after ingestion of two tablets of erythromycin (Erythrocin) stearate. Complete atelectasis of the left lung was found. The patient was treated intravenously with 200 mg of prednisolone sodium tetrahydrophthalate. On the same day the patient's condition improved dramatically and repeated chest roentgenograms disclosed an almost complete expansion of the atelectatic lung. Using the indirect mast cell degranulation test and the inhibition of direct mast cell degranulation test, we have shown the presence of IgE and non-IgE antibodies (heat stable) against erythromycin. This suggests that an allergic reaction of type 1 and type 3 participated in the course of the clinical picture.
一名患者在服用两片硬脂酸红霉素（依托红霉素）后出现严重呼吸窘迫。发现左肺完全肺不张。该患者静脉注射200毫克四氢邻苯二甲酸泼尼松龙钠进行治疗。当天患者病情显著改善，重复胸部X线检查显示肺不张的肺几乎完全复张。通过间接肥大细胞脱颗粒试验和直接肥大细胞脱颗粒抑制试验，我们发现了针对红霉素的IgE和非IgE抗体（热稳定）。这表明Ⅰ型和Ⅲ型过敏反应参与了临床表现的过程。
