Lukács G L, Mikó T L, Fábián E, Zs-Nagy I, Csáky G, Balázs G
Acta Chir Scand. 1983;149(8):759-66.
The diagnostic accuracy of intraoperative frozen section and imprint cytology in thyroid conditions was analyzed along with that of cytofluorimetric nuclear DNA determination. Of 149 frozen sections in a four-year period, 90% gave a correct diagnosis, while four results were false-positive and one was false-negative. The intraoperative accuracy of imprint cytology was 95% in 309 examinations, with 12 false-positive and four false-negative results. The misjudgements with both morphologic methods derived mainly from decisions on benignancy or malignancy of follicular tumor types. Neither atypical adenoma nor encapsulated follicular carcinoma can be conclusively distinguished with these methods. Their routine application nevertheless is of great help to the surgeon, in that they can considerably reduce the need for second (radical) operations and thus the risk of complications. Nuclear DNA determination was unhelpful in the intraoperative situation.
分析了术中冰冻切片和印片细胞学检查在甲状腺疾病中的诊断准确性，并与细胞荧光核DNA测定的诊断准确性进行了比较。在四年期间的149例冰冻切片检查中，90%给出了正确诊断，4例结果为假阳性，1例为假阴性。在309例检查中，印片细胞学检查的术中准确性为95%，有12例假阳性和4例假阴性结果。这两种形态学方法的错误判断主要源于对滤泡性肿瘤类型良恶性的判断。非典型腺瘤和包膜性滤泡癌都不能用这些方法明确区分。然而，它们的常规应用对外科医生有很大帮助，因为它们可以大大减少二次（根治性）手术的必要性，从而降低并发症的风险。核DNA测定在术中情况下没有帮助。
