[Changes in the microcirculatory bed and blood microcirculation in the mesentery of the small intestine of rabbits with experimental hypercholesterolemia].

By means of vital microscopy and some histological techniques, the dynamics of rearrangements occurring in the microcirculatory blood bed of the small intestine mesentery and changes in its blood stream have been studied in rabbits kept on the atherogenic diet for 2, 3 and 6 months. With increasing time of the experiment, diameter of arterioles and precapillaries grow smaller, the circulation rate in all groups of microvessels become slower. Capillaries, precapillaries and postcapillaries undergo reduction, the capillaries are the first to reduce and the process is most pronounced in them. Thus, under the experimental hypercholesteremia reduction of the metabolic blood flow takes place; it is possibly resulted from decreased diameters of the afferent microvessels, changes in rheological properties of blood and reduction of the metabolic microvessels owing to their prolonged switching off the circulation.