兔和大鼠肝脏及肾脏中甘氨酸N-酰基转移酶活性的围产期发育及化学预处理的影响
Perinatal development of, and effect of chemical pretreatment on, glycine N-acyltransferase activities in liver and kidney of rabbit and rat.
作者信息
James M O, Bend J R
出版信息
Biochem J. 1978 May 15;172(2):293-9. doi: 10.1042/bj1720293.
Abstract
The ontogenic development of glycine N-acyltransferase activity was studied in preparations of hepatic and renal mitochondria from the New Zealand White rabbit and the Sprague-Dawley rat. Preparations of hepatic mitochondria from the rat and the rabbit attain adult glycine N-acyltransferase specific activities by birth and 4 weeks of age respectively, whereas mitochondrial preparations from rabbit kidney do not attain adult activity until 4 months of age. Pretreatment of adult rats or immature rabbits with salicylic acid, benzoic acid or phenobarbital had little effect on glycine N-acyltransferase activity in vitro in liver or kidney.
摘要
在新西兰白兔和斯普拉格-道利大鼠的肝和肾线粒体制剂中研究了甘氨酸N-酰基转移酶活性的个体发育。大鼠和兔的肝线粒体制剂分别在出生时和4周龄时达到成年甘氨酸N-酰基转移酶的比活性，而兔肾的线粒体制剂直到4个月龄才达到成年活性。用水杨酸、苯甲酸或苯巴比妥对成年大鼠或未成熟兔进行预处理，对肝或肾中甘氨酸N-酰基转移酶的体外活性影响很小。
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