McCartney P, Keen H, Jarrett R J
Diabete Metab. 1983 Dec;9(4):303-5.
After the Bedford Survey observations were made upon retina and lens in borderline diabetics (persons with impaired glucose tolerance) and in age and sex matched controls with normal glucose tolerance. Seven years after the Survey, the prevalence of retinal abnormalities ("microaneurysms" and "exudates") was similar in each group. Of 145 initially borderline diabetics examined 10 years after the Survey, 25 had worsened to diabetes. Only two of the total group had "micro-aneurysms" present and the maximum recorded in any eye was three. Lens opacities were of similar frequency in both groups shortly after the Survey and at the seven year follow-up examination. By contrast, 24% of 79 diabetics newly diagnosed during the Survey had "microaneurysms" recorded five years later. These results further justify the diagnostic category of impaired glucose tolerance, which, at least when discovered by population screening, carries no risk of clinically apparent eye disease for at least ten years after ascertainment.
在贝德福德调查中，对糖耐量受损的临界糖尿病患者（葡萄糖耐量受损者）以及年龄和性别匹配的糖耐量正常的对照组的视网膜和晶状体进行了观察。调查七年后，每组中视网膜异常（“微动脉瘤”和“渗出物”）的患病率相似。在调查10年后对145名最初的临界糖尿病患者进行检查，其中25人病情恶化为糖尿病。在整个组中只有两人有“微动脉瘤”，任何一只眼睛中记录到的最多数量为三个。在调查后不久以及七年随访检查时，两组晶状体混浊的频率相似。相比之下，在调查期间新诊断出的79名糖尿病患者中，有24%在五年后记录到有“微动脉瘤”。这些结果进一步证明了葡萄糖耐量受损这一诊断类别是合理的，至少通过人群筛查发现时，在确诊后至少十年内不会有临床上明显的眼部疾病风险。
