Scalarone G M, Huntington R W
Mycopathologia. 1983 Nov 21;83(2):75-86. doi: 10.1007/BF00436887.
Infection was studied in mice with varying doses of spherule-endospore phase cultures of Coccidioides immitis, administered intraperitoneally, intravenously and intranasally. Stain 46 was compared with strain Silveira. The first of these is relatively avirulent in the mycelial phase, the second, rather virulent. Animals were observed for acute death and for circling. Gross and microscopic pathology was studied in mice sacrificed at appropriate intervals after infection. Numbers of fungi were assayed in spleen, lung, kidney, liver, blood, brain, and ear tissue. Strain 46 endospores administered intraperitoneally in doses from 9 X 10(6) to 2.5 X 10(7) produced a high incidence of 'circling syndrome' ataxia attributable to inner ear disease.
用不同剂量的粗球孢子菌小球体-内孢子期培养物经腹腔、静脉和鼻腔给予小鼠，研究感染情况。将菌株46与西尔韦拉菌株进行比较。前者在菌丝体阶段相对无毒力，后者则毒力较强。观察动物的急性死亡和转圈情况。对感染后在适当时间处死的小鼠进行大体和显微镜病理学研究。测定脾脏、肺、肾、肝、血液、脑和耳部组织中的真菌数量。以9×10⁶至2.5×10⁷的剂量经腹腔给予菌株46内孢子，会导致因内耳疾病引起的“转圈综合征”共济失调的高发病率。
