Kamel M M, Geddes I C
Br J Anaesth. 1978 Jun;50(6):599-603. doi: 10.1093/bja/50.6.599.
A comparison was made of the relief of pain after operation, obtained following the i.v. administration of buprenophrine and pethidine in 60 patients with lower abdominal incisions. No difference could be detected between the maximum analgesia produced by eigher drug, but analgesia following buprenorphine appeared to last about four times as long as that following pethidine. When the drugs were compared on a "dose per body weight" basis the results supported a ratio of potency in the order of 1 : 200 in favour of buprenorphine. Vomiting, drowsiness and dizziness were less frequent following buprenorphine, but a similar frequency of nausea was observed with both agents. Marked miosis occurred 5--10 min after the i.v. injection of buprenorphine, but no serious side-effects were observed with either drug. The i.v. injection of buprenorphine, but no serious side-effects were observed with either drug. The i.v. administration of buprenorphine appeared to be effective in the management of pain after operation in patients with lower abdominal incisions.
对60例下腹部手术患者静脉注射丁丙诺啡和哌替啶后的术后疼痛缓解情况进行了比较。两种药物产生的最大镇痛效果无差异，但丁丙诺啡后的镇痛持续时间似乎是哌替啶后的四倍左右。当按“每体重剂量”比较药物时，结果支持丁丙诺啡的效价比约为1:200。丁丙诺啡后呕吐、嗜睡和头晕的发生率较低，但两种药物观察到的恶心发生率相似。静脉注射丁丙诺啡后5 - 10分钟出现明显的瞳孔缩小，但两种药物均未观察到严重的副作用。静脉注射丁丙诺啡似乎对下腹部手术患者的术后疼痛管理有效。
