Finlay I G, Scott R, McArdle C S
Br Med J (Clin Res Ed). 1982 Jun 19;284(6332):1830-1. doi: 10.1136/bmj.284.6332.1830.
In a double-blind prospective trial 26 consecutive patients with proved ureteric colic were allocated at random to receive 100 mg pethidine or 0.3 mg buprenorphine by intramuscular injection. Pain relief was assessed by standard linear analogue and ordered categories scales. The mean pain relief on the linear analogue scale was 3.80 +/- SEM 0.64 in patients receiving pethidine and 6.86 +/- 0.40 in those receiving buprenorphine (p less than 0.001). The corresponding values for mean pain relief in the ordered categories scale was 1.78 +/- 0.26 v 2.76 +/- 0.20 (p less than 0.01). These observations suggest that buprenorphine is superior to pethidine as analgesia in ureteric colic.
在一项双盲前瞻性试验中,26例确诊为输尿管绞痛的连续患者被随机分配,分别接受100毫克哌替啶或0.3毫克丁丙诺啡肌肉注射。通过标准线性模拟量表和有序分类量表评估疼痛缓解情况。接受哌替啶的患者在线性模拟量表上的平均疼痛缓解为3.80±标准误0.64,接受丁丙诺啡的患者为6.86±0.40(p<0.001)。在有序分类量表中,平均疼痛缓解的相应值为1.78±0.26对2.76±0.20(p<0.01)。这些观察结果表明,在输尿管绞痛的镇痛方面,丁丙诺啡优于哌替啶。