Kodama T, Reddy V N, Giblin F, Kinoshita J H, Harding C
Ophthalmic Res. 1983;15(6):324-33. doi: 10.1159/000265280.
The possible multiple effect of galactose diet and X-irradiation on cataract development in mice was investigated by scanning electron microscopy. X-ray cataracts were induced by maintaining animals either on a normal or 50% galactose diet. No detectable changes in lens morphology were seen in animals fed galactose alone compared with normal controls. 2 months after X-ray, less damage had occurred to the lenses of the galactose-fed animals compared to those on a normal diet. At 4 months after X-ray, animals on a normal diet developed mature cataracts, while in the galactose-fed animals they were delayed by 0.5-1.5 months. Suppression of the development of X-ray cataract by galactose feeding may be related to the ability of this sugar, which accumulates in mouse lens due to the low levels of aldose reductase, to act as a free radical scavenger.
通过扫描电子显微镜研究了半乳糖饮食和X射线对小鼠白内障形成的可能多重影响。通过将动物维持在正常或50%半乳糖饮食中来诱导X射线白内障。与正常对照组相比，单独喂食半乳糖的动物晶状体形态未见可检测到的变化。X射线照射2个月后，与正常饮食的动物相比，喂食半乳糖的动物晶状体损伤较小。X射线照射4个月后，正常饮食的动物出现了成熟白内障，而喂食半乳糖的动物则延迟了0.5 - 1.5个月。喂食半乳糖抑制X射线白内障的发展可能与这种糖的能力有关，由于醛糖还原酶水平较低，这种糖在小鼠晶状体中积累，可作为自由基清除剂。
