[Effect of chloroquine diphosphate on the superhelix structure of DNA and protein synthesis in synovial cells in chronic polyarthritis].

The influence of chloroquine diphosphate on protein synthesis in synovial fluid cells was investigated in 8 patients suffering from rheumatoid arthritis. Intraarticular injection of chloroquine diphosphate at a dose of 25 mg and 50 mg is followed a small decrease in incorporation of 3H-marked amino acids into the synovial fluid cells. Above a dose of 100 mg the protein synthesis is significant reduced. In a second experiment the supercoiled structure of DNA under C1Q was lost. After 2 hours the chain breaks were repaired.