Micheau C, Richard J M, Marandas P, Bosq J, Caillaud J M
Ann Otolaryngol Chir Cervicofac. 1983;100(8):577-80.
Few pathologists have given much thought to the problem of post-chemotherapeutic tumoral regression of upper respiratory and digestive tract carcinoma. In other oncological fields (pediatry: nephroblastoma, embryonic sarcoma, osteosarcoma; gynecology: mammary tumors...) pre- and post-chemotherapy tissue studies have led to histological grading of prognostic value (particularly well known is that of Rosen et al). Numerous specimens were examined following operations for cancer, including pelvimandibulectomy, buccopharyngectomy, facial resection... Possible tumoral changes were evaluated using a conventional scale of regression based on 6 histologic degrees, and findings were of prognostic significance when compared with the initial biopsy results. This evaluation scale may require modification in the near future since recently introduced chemotherapy, particularly cisplatinum, appears to have a more potent and more specific effect on histologie features.
很少有病理学家对化疗后上呼吸道和消化道癌的肿瘤消退问题进行过多思考。在其他肿瘤学领域（儿科学：肾母细胞瘤、胚胎肉瘤、骨肉瘤；妇科：乳腺肿瘤……），化疗前后的组织学研究已得出具有预后价值的组织学分级（尤其是罗森等人的分级广为人知）。在癌症手术后检查了大量标本，包括骨盆下颌骨切除术、颊咽切除术、面部切除术……使用基于6个组织学程度的传统消退量表评估可能的肿瘤变化，与初始活检结果相比，这些发现具有预后意义。由于最近引入的化疗，尤其是顺铂，似乎对组织学特征有更强效、更特异的作用，因此该评估量表可能在不久的将来需要修改。
