Pretolani E, Zoli I, Battistini G, Salvi P
Boll Soc Ital Biol Sper. 1983 Dec 30;59(12):1819-24.
The aim of this paper is to test whether an alteration of blood flow in microcirculation and in particular of red cell deformability is present in myocardial ischaemia. To this end we determined by the method proposed by Reid and Dormandy (J. Clin. Pharmacol. 1976, 29, 855) whole-blood filterability in 23 patients with myocardial ischaemia, in 15 clinically healthy subjects and in 99 subjects without clinical evidence of ischemic pathology displaying one or more vascular risk factors. Blood filterability turned out to be significantly lower in cases of coronary diseases than in controls (p less than 0,001), while it was lower but not significantly so, than in subjects displaying risk factors. We conclude therefore that the presence of risk factors is enough important to be considered one of the fundamental elements (though non the only one) in causing the reduction of blood-filterability encountered in ischemic cardiopathology.
本文旨在检验心肌缺血时是否存在微循环血流改变，尤其是红细胞变形性改变。为此，我们采用里德和多尔曼迪（《临床药理学杂志》，1976年，第29卷，第855页）提出的方法，测定了23例心肌缺血患者、15例临床健康受试者以及99例无缺血性病理临床证据但有一个或多个血管危险因素的受试者的全血过滤性。结果发现，冠心病患者的血液过滤性显著低于对照组（p<0.001），而与有危险因素的受试者相比虽较低但无显著差异。因此，我们得出结论，危险因素的存在非常重要，足以被视为导致缺血性心脏病中血液过滤性降低的基本因素之一（尽管不是唯一因素）。
