Shahar E, Barzilay Z, Shohet I, Altman G, Cohen B E
Acta Paediatr Hung. 1983;24(3):263-7.
Infection with brucella microorganisms is considered uncommon in the paediatric age group. We report nine paediatric patients between the ages of 8 to 17 years with acute Brucella melitensis infection, who presented with spiking fever, night sweats, anorexia and malaise for 5 to 60 days prior to diagnosis. Four patients developed various osteoarticular complications: migratory arthralgia, hydroarthrosis of the knees, arthritis and osteomyelitis. Therapy with tetracyclines alone or in combination with streptomycin resulted in complete recovery in eight children. This combination failed in one patient who developed severe osteoarticular disease successfully responding to rifampicin. Since infection of bone and joints leads to irreversible damage, early recognition and immediate management are crucial for recovery. Rifampicin might be of benefit in children with severe osteoarticular complications when the traditional anti-brucella regimen fails.
布鲁氏菌微生物感染在儿童年龄组中被认为不常见。我们报告了9例8至17岁的急性羊布鲁氏菌感染的儿科患者，他们在诊断前5至60天出现高热、盗汗、厌食和不适。4例患者出现了各种骨关节并发症：游走性关节痛、膝关节滑膜炎、关节炎和骨髓炎。单独使用四环素或与链霉素联合治疗使8名儿童完全康复。这种联合治疗在1例发展为严重骨关节疾病的患者中失败，该患者对利福平治疗成功有反应。由于骨骼和关节感染会导致不可逆转的损害，早期识别和立即处理对于康复至关重要。当传统的抗布鲁氏菌治疗方案失败时，利福平可能对患有严重骨关节并发症的儿童有益。
