Helgstrand U
Scand J Gastroenterol. 1983 Mar;18(2):317-9. doi: 10.3109/00365528309181600.
The mucosal fibrinolytic activity was estimated in 14 patients with duodenal ulcer before and after 4 weeks' treatment with cimetidine. A significant reduction in fibrinolytic activity in the corpus and antrum mucosa was found after treatment. In patients with healed ulcer after treatment, the activity was lower than in patients with unhealed ulcers, but no significance was proved. Similarly, in five patients with gastric ulcer, reduction in fibrinolytic activity was found after cimetidine treatment but in the corpus mucosa only. The fibrinolytic activity in the mucosa is caused by plasmin. Whether this antifibrinolytic property of cimetidine is of any importance in the treatment of ulcer disease is still unknown.
对14例十二指肠溃疡患者在使用西咪替丁治疗4周前后的黏膜纤溶活性进行了评估。治疗后发现胃体和胃窦黏膜的纤溶活性显著降低。治疗后溃疡愈合的患者，其活性低于溃疡未愈合的患者，但未证实有显著性差异。同样，在5例胃溃疡患者中，西咪替丁治疗后仅胃体黏膜的纤溶活性降低。黏膜中的纤溶活性由纤溶酶引起。西咪替丁的这种抗纤溶特性在溃疡病治疗中是否具有重要意义仍不清楚。
