Petersen B, Steen J, Christiansen J
Scand J Gastroenterol. 1983 Nov;18(8):1101-7. doi: 10.3109/00365528309181848.
Fasting and meal-stimulated NH2-terminal gastrin concentrations in serum were significantly higher in patients with active duodenal ulcer than in control subjects and in patients with inactive duodenal ulcer (p less than 0.05). In contrast, the COOH-terminal gastrin concentrations (the bioactive gastrins) did not differ among the groups. Parallel variation in the NH2- and COOH-terminal gastrin concentrations occurred both during meal stimulation and as response to adrenaline or secretin infusion. In a longitudinal study of duodenal ulcer patients, higher NH2- than COOH-terminal gastrin concentrations were associated with the active phase of the disease, whereas this seldom occurred during the inactive phase (p less than 0.001). These data suggest that abnormally large amounts of the NH2-terminal fragment of gastrin-17 are released to the circulation during the active phase of duodenal ulcer.
与对照组和十二指肠溃疡非活动期患者相比，十二指肠溃疡活动期患者血清中空腹及进餐刺激后的氨基末端胃泌素浓度显著更高（p<0.05）。相比之下，羧基末端胃泌素浓度（生物活性胃泌素）在各组之间并无差异。在进餐刺激期间以及对肾上腺素或促胰液素输注的反应过程中，氨基末端和羧基末端胃泌素浓度呈平行变化。在一项对十二指肠溃疡患者的纵向研究中，氨基末端胃泌素浓度高于羧基末端胃泌素浓度与疾病的活动期相关，而在非活动期这种情况很少发生（p<0.001）。这些数据表明，在十二指肠溃疡活动期，胃泌素-17的氨基末端片段会异常大量释放入血。
