Berant M, Diamond E, Brik R, Yurman S
Acta Paediatr Scand. 1983 Nov;72(6):853-5. doi: 10.1111/j.1651-2227.1983.tb09829.x.
The concentration of fecal bile salts was measured in 14 jaundiced neonates who received phototherapy (PT group) and their 14 nontreated matched controls (C). Before initiation of phototherapy, mean bile salt concentrations in stool specimens from the two groups were similar. At 12 hours of 'lights on', stool specimens from PT babies showed a significantly increased mean bile salt concentration, whereas in the C babies there was no change (3.65 +/- 0.39 vs 2.62 +/- 0.22 mmol/l; p less than 0.01). At 24 hours after 'lights off', stool specimens from the PT infants had a mean bile salt concentration like that before phototherapy, and not different from C. During phototherapy, nine PT babies had a bile salt concentration in their stools of 3.5 mmol/l and above; 6 of these babies had watery stools with a high sodium content. The high concentration of bile salts found in the colonic contents of neonates during phototherapy would appear to be a factor in the pathogenesis of phototherapy-associated diarrhea in the jaundiced neonate.
对14名接受光疗的黄疸新生儿（光疗组，PT组）及其14名未接受治疗的配对对照婴儿（对照组，C组）的粪便胆汁盐浓度进行了测量。在开始光疗前，两组婴儿粪便标本中的平均胆汁盐浓度相似。在“光照开启”12小时时，光疗组婴儿的粪便标本显示平均胆汁盐浓度显著升高，而对照组婴儿则无变化（3.65±0.39 vs 2.62±0.22 mmol/L；p<0.01）。在“光照关闭”24小时后，光疗组婴儿粪便标本的平均胆汁盐浓度与光疗前相似，且与对照组无差异。在光疗期间，9名光疗组婴儿粪便中的胆汁盐浓度达到3.5 mmol/L及以上；其中6名婴儿出现高钠含量的水样便。光疗期间在新生儿结肠内容物中发现的高浓度胆汁盐似乎是黄疸新生儿光疗相关性腹泻发病机制中的一个因素。
