Berant M, Brik R, Alon U, Makhul I, Diamond E, Mordochowitz D
Biol Neonate. 1984;45(1):11-6. doi: 10.1159/000241757.
We studied the acute effects of phototherapy (PT) on bile flow and on the biliary excretion of bilirubin pigments and of bile salts in male homozygous Gunn rats (120-150 g). 13 rats received PT and 10 rats were kept in the dark. Bile was collected by cannulation of the common bile duct at hourly intervals from 1 h prior to PT till after 4 h of 'lights on'. Before treatment, all values were similar in both groups. After 4 h of lights on, mean plasma bilirubin fell from 145.3 +/- 4.3 to 99.2 +/- 2.7 mumol/l (p less than 0.01) in the PT rats, but did not change in the controls. During the lights-on period, PT rats had a significantly higher hourly bile volume, and a higher excretion of biliary bilirubin and bile salts than the controls (p less than 0.005). Over the total 4-hour lights-on period, the PT group had a higher mean output of bile than the controls (0.93 +/- 0.17 vs. 1.52 +/- 0.34 ml/4 h; p less than 0.005) and an increased excretion of bilirubin (0.08 +/- 0.016 vs. 0.148 +/- 0.01 mumol/4 h; p less than 0.005) and bile salts (35.1 +/- 3.7 vs. 55.2 +/- 12.5 mumol/4 h; p less than 0.005). The results show that PT of the Gunn rat is associated with a rise in bile flow and with an increased excretion of bile salts, in addition to an increased biliary bilirubin output.
我们研究了光疗（PT）对雄性纯合子冈恩大鼠（120 - 150克）胆汁流量、胆红素色素和胆盐胆汁排泄的急性影响。13只大鼠接受光疗，10只大鼠置于黑暗环境中。通过在胆总管插管，从光疗前1小时直至“光照开启”4小时后，每隔1小时收集胆汁。治疗前，两组的所有数值相似。光照开启4小时后，光疗组大鼠的平均血浆胆红素从145.3±4.3降至99.2±2.7微摩尔/升（p＜0.01），而对照组未发生变化。在光照期间，光疗组大鼠每小时的胆汁量显著高于对照组，胆汁胆红素和胆盐的排泄量也高于对照组（p＜0.005）。在整个4小时的光照期间，光疗组的平均胆汁输出量高于对照组（0.93±0.17对1.52±0.34毫升/4小时；p＜0.005），胆红素排泄增加（0.08±0.016对0.148±0.01微摩尔/4小时；p＜0.005），胆盐排泄增加（35.1±3.7对55.2±12.5微摩尔/4小时；p＜0.005）。结果表明，冈恩大鼠的光疗除了增加胆汁胆红素输出外，还与胆汁流量增加和胆盐排泄增加有关。
