Marhaug G, Permin H, Husby G
Acta Paediatr Scand. 1983 Nov;72(6):861-6. doi: 10.1111/j.1651-2227.1983.tb09831.x.
Amyloid-related serum protein (SAA) was analysed by radioimmunoassay in 32 patients with cystic fibrosis, and compared with other acute phase reactants and lung function. The level of SAA showed significant correlation with impaired lung function due to active Pseudomonas aeruginosa infection, and also to C-reactive protein. SAA seemed to correlate better to the presence of bacteria in sputum than C-reactive protein. Ten of the patients received extensive antibiotic treatment for their pulmonary infection, and falling serum levels of SAA paralleled the clinical response to treatment. Thus the concentration of SAA in these patients was a valuable guide for the selection of patients for antibiotic treatment as well as a good parameter of the response to therapy.
采用放射免疫分析法对32例囊性纤维化患者的淀粉样相关血清蛋白（SAA）进行了分析，并与其他急性期反应物及肺功能进行了比较。SAA水平与因铜绿假单胞菌活跃感染导致的肺功能受损以及C反应蛋白均呈显著相关。SAA与痰液中细菌的存在情况似乎比C反应蛋白的相关性更好。其中10例患者因肺部感染接受了广泛的抗生素治疗，血清SAA水平下降与治疗的临床反应平行。因此，这些患者体内SAA的浓度是选择抗生素治疗患者的有价值指标，也是治疗反应的良好参数。
