Ostensen M, Marhaug G, Husby G
Acta Pathol Microbiol Immunol Scand C. 1985 Feb;93(1):1-5. doi: 10.1111/j.1699-0463.1985.tb02913.x.
The usefulness of amyloid-related serum protein (SAA) as an indicator of disease activity has been evaluated in 11 patients with rheumatoid arthritis (RA), 2 patients with psoriatic arthritis (PA) and 13 patients with ankylosing spondylitis (AS) prospectively studied during and after pregnancy. For comparison, SAA levels were recorded serially during and after pregnancy in 28 healthy pregnant women. SAA levels were unaltered by gestation and thus within the normal range during normal pregnancy, but were raised in healthy pregnant women with episodes of intercurrent infections. In RA and AS patients, SAA concentrations correlated to disease activity during and after pregnancy. Serial levels of SAA and C-reactive protein in healthy women and patients paralleled each other with the most pronounced inflammatory response displayed by SAA. We conclude that SAA is a sensitive and reliable indicator of inflammatory events both in the pregnant and non-pregnant state.
在11例类风湿关节炎（RA）患者、2例银屑病关节炎（PA）患者和13例强直性脊柱炎（AS）患者中，前瞻性地研究了妊娠期间及产后淀粉样蛋白相关血清蛋白（SAA）作为疾病活动指标的有用性。为作比较，记录了28名健康孕妇妊娠期间及产后的SAA水平。妊娠对SAA水平无影响，因此正常妊娠期间SAA水平在正常范围内，但并发感染的健康孕妇SAA水平会升高。在RA和AS患者中，SAA浓度与妊娠期间及产后的疾病活动相关。健康女性和患者的SAA和C反应蛋白系列水平相互平行，SAA表现出最明显的炎症反应。我们得出结论，SAA是妊娠和非妊娠状态下炎症事件的敏感且可靠指标。
