不同年龄组正常人群的血清淀粉样蛋白A（SAA）水平。
Levels of the serum amyloid A protein (SAA) in normal persons of different age groups.
作者信息
Hijmans W, Sipe J D
出版信息
Clin Exp Immunol. 1979 Jan;35(1):96-100.
Abstract
Serum amyloid A (SAA) has been implicated by three independent studies to increase in concentration with ageing. The present study measured SAA concentration in 395 samples from 302 healthy individuals ranging in age from 21 to 100 years. The average SAA concentration was 20 microgram/ml, with only five serum samples falling below 5 microgram/ml. SAA concentrations are expressed in terms of cross-reactivity of purified, denatured SAA with anti-AA antibodies, rather than the purified, denatured amyloid fibril protein AA from tissues, which has been used in the past. No age-related increase in SAA concentration was observed in the present study. The average SAA concentration in these normal, healthy individuals was almost a hundred-fold less than values measured in acute phase human serum in a separate study with the same reagents.
摘要
三项独立研究表明，血清淀粉样蛋白A（SAA）的浓度会随着年龄增长而升高。本研究测定了302名年龄在21岁至100岁之间的健康个体的395份样本中的SAA浓度。SAA的平均浓度为20微克/毫升，只有五份血清样本低于5微克/毫升。SAA浓度是根据纯化的、变性的SAA与抗AA抗体的交叉反应性来表示的，而不是像过去那样根据组织中纯化的、变性的淀粉样原纤维蛋白AA来表示。在本研究中未观察到SAA浓度随年龄增长而升高。在另一项使用相同试剂的研究中，这些正常健康个体的SAA平均浓度几乎比急性期人血清中的测定值低一百倍。
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