Dumas M, Breton J C, Pestre-Alexandre M, Nicolas J A, Catanzano G
Bull Soc Pathol Exot Filiales. 1983 Nov;76(5):622-7.
The melarsoprol is still the only active drug during the nervous stage of African human trypanosomiasis, its prescription still relies on empiric rules and because of its toxicity, it appears necessary to study in gaseous phase chromatography and mass spectrometry, its pharmacokinetic in the serum and the cerebrospinal fluid (CSF) of the patients at the evolutive stage of the illness. Because of the early penetration of the Trypanosoma into the central nervous system, new therapeutic investigations should only search molecules capable to pass through the blood brain barrier: this in unfortunately not always the case, the rifamycins diffusing easily into CSF, they seem to offer a reliable way of research. For these therapeutic investigations, sheep is an easy to handle experimental model and of a reasonable cost.
美拉胂醇仍然是非洲人类锥虫病神经期唯一的活性药物，其处方仍依赖经验规则，并且由于其毒性，似乎有必要通过气相色谱和质谱法研究其在疾病进展期患者血清和脑脊液中的药代动力学。由于锥虫早期侵入中枢神经系统，新的治疗研究应只寻找能够穿过血脑屏障的分子：不幸的是情况并非总是如此，利福霉素很容易扩散到脑脊液中，它们似乎提供了一种可靠的研究途径。对于这些治疗研究，绵羊是一种易于操作且成本合理的实验模型。
