Bouteille B, Darde M L, Monteil J, Pestre-Alexandre M
Service de Parasitologie-Mycologie, C. H. U. Dupuytren, Limoges.
Bull Soc Pathol Exot Filiales. 1988;81(3 Pt 2):522-31.
Broad variations in complement levels are seen during the course of many infectious diseases, particularly human and animal african trypanosomiasis. In this study, sheep complement is measured by means of its haemolytic activity expressed in 50% haemolytic complement units per ml (HCU50/ml). In healthy sheep, the average value is 23.3 HCU50/ml. Complement levels dramatically decrease five days after subcutaneous inoculation of Trypanosoma brucei brucei and remain undetectable until death of non treated infected animals. Eight infected sheep are treated with graded dosages of melarsoprol when central nervous system involvement appeared. Complement levels rapidly recover normal values after efficient treatment (0.9 and 1.8 mg/kg/d).
在许多传染病病程中可观察到补体水平的广泛变化，尤其是人类和动物的非洲锥虫病。在本研究中，通过以每毫升50%溶血补体单位（HCU50/ml）表示的溶血活性来测定绵羊补体。健康绵羊的平均值为23.3 HCU50/ml。皮下接种布氏布氏锥虫五天后补体水平急剧下降，在未治疗的感染动物死亡前一直检测不到。当出现中枢神经系统受累时，八只感染绵羊接受不同剂量的美拉胂醇治疗。有效治疗（0.9和1.8毫克/千克/天）后补体水平迅速恢复到正常值。
