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坦桑尼亚一家乡村医院的锥虫病。对其管理及治疗结果的回顾性研究。

Trypanosomiasis in a rural hospital in Tanzania. A retrospective study of its management and the results of treatment.

作者信息

Veeken H J, Ebeling M C, Dolmans W M

机构信息

Kabanga Hospital, Tanzania.

出版信息

Trop Geogr Med. 1989 Apr;41(2):113-7.

PMID:2763355
Abstract

A retrospective analysis was done of the management and the results of treatment in 158 trypanosomiasis patients seen in a rural hospital in Tanzania during 1985. The distribution of cases in the population and during the year reflected an endemic situation. 109 patients (68.9%) were in the meningoencephalitic (ME) stage and 49 (31.1%) in the hematolymphatic (HL) stage of the disease. In total 19 patients (12.0%) died, 17 with ME and 2 with HL trypanosomiasis. Encephalopathy was seen in 19 (17.9%) of 106 patients treated with melarsoprol, and 10 of them died. In 15 (24.4%) of 64 patients who were discharged as HL trypanosomiasis evidence of CNS-involvement was found during follow-up after 3 and/or 9 months.

摘要

对1985年在坦桑尼亚一家乡村医院就诊的158例锥虫病患者的治疗管理及结果进行了回顾性分析。病例在人群中的分布以及全年的分布情况反映出该病为地方病流行态势。109例患者(68.9%)处于脑膜脑炎(ME)期,49例(31.1%)处于疾病的血液淋巴(HL)期。共有19例患者(12.0%)死亡,其中17例死于ME期锥虫病,2例死于HL期锥虫病。在接受美拉胂醇治疗的106例患者中,19例(17.9%)出现脑病,其中10例死亡。在64例以HL期锥虫病出院的患者中,15例(24.4%)在3个月和/或9个月的随访期间发现有中枢神经系统受累的证据。

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引用本文的文献

1
Immunopathology of experimental African sleeping sickness: detection of cytokine mRNA in the brains of Trypanosoma brucei brucei-infected mice.实验性非洲昏睡病的免疫病理学:检测布氏布氏锥虫感染小鼠大脑中的细胞因子mRNA
Infect Immun. 1991 Dec;59(12):4636-40. doi: 10.1128/iai.59.12.4636-4640.1991.