Cohn M, Epstein R
Scand J Immunol. 1977;6(1-2):39-58. doi: 10.1111/j.1365-3083.1977.tb00321.x.
Evidence is presented that the induction of a humoral response is inhibitable by a thymus-derived cell (TI) that acts on the antigen-sensitive precursors of both the thymus-derived cooperating and the bone marrow-derived antibody-secreting cell-that is, the tC and B cell respectively. The inhibition of induction of the tC and B cell by the TI cell is shown to be reversed by increasing the effective level of cooperation. This competitive interaction between the inhibitory (TI) and cooperating (TC) systems is postulated to be part of the mechanism for regulating the class of the response, cell-mediated or humoral. The following properties of the inhibitory system were demonstrated: [1] The tI cell--the antigen-sensitive precursor of the TI cell--is both paralyzable and inducible. [2] The TI cell appears during the induction of a cell-mediated response and, if not identical to the effector cytotoxic ('killer') TK cell, the TI cell is induced in parallel with it. [3] The effector function of the TI cell, like that of the TK cell, is H-2-restricted.
有证据表明，胸腺来源的细胞（TI）可抑制体液反应的诱导，该细胞作用于胸腺来源的协同细胞和骨髓来源的抗体分泌细胞（分别为tC细胞和B细胞）的抗原敏感前体细胞。通过提高协同的有效水平，TI细胞对tC细胞和B细胞诱导的抑制作用可被逆转。抑制性（TI）系统和协同性（TC）系统之间的这种竞争性相互作用被认为是调节细胞介导或体液反应类型机制的一部分。已证明抑制系统具有以下特性：[1] tI细胞（TI细胞的抗原敏感前体细胞）既可以被麻痹也可以被诱导。[2] TI细胞在细胞介导反应的诱导过程中出现，并且如果与效应细胞毒性（“杀伤”）TK细胞不同，TI细胞与它同时被诱导。[3] TI细胞的效应功能与TK细胞一样，受H-2限制。
