Chaine G, Kohner E M
J Fr Ophtalmol. 1983;6(12):995-1005.
Retinal blood vessels differ from most other vessels in the body (with the exception of those in the brain) in two important respects. The first is the presence of blood-retinal barriers, best illustrated by fluorescein angiography. The second important difference is that retinal vessels do not have sympathetic innervation and blood flow is modulated by autoregulation mechanisms. In 1939 Keith, Wagener and Barker proposed a classification system for hypertensive retinopathy which was innovative and of prognostic importance at that time. However, the different features of hypertensive and arteriosclerotic vasculopathies are not adequately distinguished by this classification system. Clinical features of accelerated hypertension are retinal haemorrhages, cotton wool-spots, hard exudates, papilloedema and increased vascular permeability. These must be differentiated from features associated with arteriosclerosis which are arteriovenous crossing changes and arterial constriction. The advantages of the Hogan classification system, based up on histopathologic and pathogenetic considerations are discussed. Other retinal vascular diseases associated with hypertension are also mentioned. Such as toxaemia of pregnancy, arterial macroaneurysm and anterior ischaemic optic neuropathy. Retinal branch vein occlusion is rather associated with arteriosclerosis than with hypertension.
视网膜血管在两个重要方面不同于身体的大多数其他血管(大脑中的血管除外)。第一个方面是存在血视网膜屏障,荧光素血管造影对此有最好的体现。第二个重要区别是视网膜血管没有交感神经支配,血流由自身调节机制调节。1939年,基思、瓦格纳和巴克提出了一种高血压视网膜病变的分类系统,该系统在当时具有创新性且具有预后重要性。然而,该分类系统并未充分区分高血压性和动脉硬化性血管病变的不同特征。急进性高血压的临床特征是视网膜出血、棉絮斑、硬性渗出、视乳头水肿和血管通透性增加。这些必须与动脉硬化相关的特征区分开来,后者是动静脉交叉改变和动脉狭窄。讨论了基于组织病理学和发病机制考虑的霍根分类系统的优点。还提到了与高血压相关的其他视网膜血管疾病。如妊娠中毒症、动脉大动脉瘤和前部缺血性视神经病变。视网膜分支静脉阻塞与动脉硬化的相关性大于与高血压的相关性。