Tanaka M, Kawabata S, Nishino T, Tanino T
Jpn J Antibiot. 1983 Oct;36(10):2869-80.
The combined actions of cefoxitin (CFX) with amikacin (AMK), gentamicin (GM) and dibekacin (DKB) were studied against Gram-positive and Gram-negative bacteria. The following results were obtained. The synergistic actions of CFX with AMK, GM and DKB were observed on S. aureus, S. epidermidis, E. coli, S. marcescens, K. pneumoniae, Proteus spp. and Acinetobacter by checker board titration method. The combination of CFX with AMK was most effective. In case of the combination of CFX with AMK, the simultaneous administration showed the highest bactericidal effect, followed by the case of addition of AMK after adding CFX. The phase-contrast microscopic observation on S. marcescens revealed that the bacterial cell prolonged with CFX showed a filament-like form and with AMK almost a normal form. In the combination, lysed cells were observed. The therapeutic experiment of S. marcescens infection in mice demonstrated that the combination of CFX with AMK showed superior effect than that of each drug alone.
研究了头孢西丁（CFX）与阿米卡星（AMK）、庆大霉素（GM）和地贝卡星（DKB）联合对革兰氏阳性菌和革兰氏阴性菌的作用。获得了以下结果。通过棋盘滴定法观察到CFX与AMK、GM和DKB对金黄色葡萄球菌、表皮葡萄球菌、大肠杆菌、粘质沙雷氏菌、肺炎克雷伯菌、变形杆菌属和不动杆菌具有协同作用。CFX与AMK的组合最有效。在CFX与AMK组合的情况下，同时给药显示出最高的杀菌效果，其次是在加入CFX后再加入AMK的情况。对粘质沙雷氏菌的相差显微镜观察显示，用CFX处理的细菌细胞呈丝状，而用AMK处理的几乎呈正常形态。在联合使用中，观察到细胞裂解。小鼠粘质沙雷氏菌感染的治疗实验表明，CFX与AMK的组合比单独使用每种药物显示出更好的效果。
