头孢西丁：在体外与氨基糖苷类药物有协同作用。
Cefoxitin: synergism with aminoglycosides in vitro.
作者信息
Une T, Osada Y, Ogawa H
出版信息
Arzneimittelforschung. 1981;31(5):761-4.
In vitro synergistic effect of cefoxitin with aminoglycosides such as gentamicin, tobramycin, amikacin and dibekacin against 15 Escherichia coli, 15 Staphylococcus aureus and 105 Pseudomonas aeruginosa strains of fresh clinical isolates was examined. The combination of cefoxitin with the aminoglycosides showed distinct synergy against many strains of P. aeruginosa which were highly resistant to cefoxitin alone, while it failed in synergism against E. coli and S. aureus. A possible mechanism of in vitro synergy between cefoxitin and aminoglycosides against P. aeruginosa was discussed.
考察了头孢西丁与庆大霉素、妥布霉素、阿米卡星和地贝卡星等氨基糖苷类药物对15株新鲜临床分离的大肠杆菌、15株金黄色葡萄球菌和105株铜绿假单胞菌的体外协同作用。头孢西丁与氨基糖苷类药物联合使用对许多单独对头孢西丁高度耐药的铜绿假单胞菌菌株显示出明显的协同作用，而对大肠杆菌和金黄色葡萄球菌则未显示出协同作用。讨论了头孢西丁与氨基糖苷类药物对铜绿假单胞菌体外协同作用的可能机制。
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