Tanaka N, Yoshihara H, Ono M, Moritani T, Terasawa A, Beika T, Mannami T, Konaga E, Mimura H, Kunzo O
Nihon Geka Gakkai Zasshi. 1983 Mar;84(3):203-10.
The effects of anesthesia and surgical procedures on natural killer (NK) cell activity were studied. The data indicated that splenic lymphocytes taken from mice 1 to 5 days after surgery showed significantly diminished activity of natural killing. When splenic lymphocytes were treated by anti-Thy 1 antibody and complement, NK activity to Lewis lung carcinoma cells was remarkably depressed in normal mice, but was not depressed in laparotomized mice. Peripheral lymphocytes from cancer patients following major surgery also showed depressed NK activity. The suppression was first detected during the operation. In patients undergoing major gastrointestinal surgery, the suppression was at its maximum during first three days and decreased to control levels by the day 7 to 14. Following major thoracic surgery, the suppression continued more longer.
研究了麻醉和外科手术对自然杀伤（NK）细胞活性的影响。数据表明，在手术后1至5天从小鼠获取的脾淋巴细胞显示出自然杀伤活性显著降低。当用抗Thy 1抗体和补体处理脾淋巴细胞时，正常小鼠对Lewis肺癌细胞的NK活性明显降低，但剖腹手术小鼠的NK活性并未降低。大手术后癌症患者的外周淋巴细胞也显示出NK活性降低。这种抑制在手术过程中首次被检测到。在接受重大胃肠手术的患者中，抑制在头三天达到最大程度，并在第7至14天降至对照水平。重大胸科手术后，抑制持续的时间更长。
