Fujii N, Fujita T, Kawazoe K, Ego Y, Kosakai Y, Ohara K, Kito Y, Manabe H, Nakajima K
Nihon Geka Gakkai Zasshi. 1983 May;84(5):379-86.
The Ionescu-Shiley bovine pericardial xenograft (ISPX) has been widely accepted clinically because of its superior hemodynamic characteristics and low incidence of thrombogenicity. After confirmation by our own experiment of its superior valve performance, we have adopted in clinical application of this valve since August of 1979, and implanted 189 of this valve in 170 patients up to November of 1981. The overall mortality rate including of hospital and follow up death was 14.1%. The pressure gradient and calculated orifice area of ISPX were compared to those of Hancock xenograft (HX), and the valve characteristics of ISPXs was found to be better than those of HX. The cardiac function following implantation of this valve apparently showed improvement. No incidence of thromboembolic episode or malfunction was observed, however, prosthetic valve endocarditis (PVE) was encountered in four patients and two died. This incidence of PVE in ISPXs was not significantly higher in comparison to that in other type of prosthetic valve. However the low incidence of thromboembolic episode as well as acceptable valve performance were confirmed by our study, the durability and susceptibility to PVE has to be carefully observed in the longer follow up.
伊奥内斯库-希利牛心包异种移植瓣膜（ISPX）因其优异的血流动力学特性和较低的血栓形成发生率而在临床上被广泛接受。在我们自己的实验证实其瓣膜性能优越后，自1979年8月起我们在临床应用中采用了这种瓣膜，截至1981年11月，已在170例患者中植入了189个这种瓣膜。包括住院死亡和随访死亡在内的总死亡率为14.1%。将ISPX的压力阶差和计算得出的瓣口面积与汉考克异种移植瓣膜（HX）的进行比较，发现ISPX的瓣膜特性优于HX。植入该瓣膜后心脏功能明显改善。未观察到血栓栓塞事件或瓣膜功能障碍的发生，然而，有4例患者发生了人工瓣膜心内膜炎（PVE），其中2例死亡。与其他类型的人工瓣膜相比，ISPX中PVE的发生率没有显著更高。尽管我们的研究证实了血栓栓塞事件的低发生率以及可接受的瓣膜性能，但在更长时间的随访中必须仔细观察其耐久性和对PVE的易感性。
