Niemann-Pick disease experimental model: sphingomyelinase reduction induced by AY-9944.
作者信息
Sakuragawa N, Sakuragaw M, Kuwabara T, Pentchev P G, Barranger J A, Brady R O
出版信息
Science. 1977 Apr 15;196(4287):317-9. doi: 10.1126/science.66749.
PMID:66749
Abstract
Organs of rats treated with the drug A Y-9944 for 5 days showed a significant reduction in sphingomyelinase activity. Evidence is presented which suggests that the reduction is due to impaired enzyme synthesis.
摘要
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