Fukuda A, Sugiura A
Jpn J Med Sci Biol. 1983 Dec;36(6):331-5. doi: 10.7883/yoken1952.36.331.
Temperature-dependent growth restriction was studied with the measles vaccine strains licensed in Japan in comparison with their parental wild strains. Plaquing efficiency was compared at various temperatures from 35 to 40 C. AIK-C strain derived from Edmonston wild strain was temperature-sensitive with the 39 C shutoff temperature. No significant restriction of growth was found for other vaccine strains, i.e., Schwarz, FF-8, and CAM-70, and for their parental wild strains, i.e., Edmonston and Tanabe . A paradoxical feature was found for FF-8 strain; in spite of undiminished plaquing efficiency at 40 C, the growth in the fluid medium was markedly depressed at 39 C or above.
将日本许可使用的麻疹疫苗株与其亲本野生株进行比较，研究了温度依赖性生长限制。在35至40℃的不同温度下比较了空斑形成效率。源自埃德蒙斯顿野生株的AIK-C株对温度敏感，关闭温度为39℃。未发现其他疫苗株（即施瓦茨株、FF-8株和CAM-70株）及其亲本野生株（即埃德蒙斯顿株和田边株）的生长有明显限制。FF-8株有一个矛盾的特征；尽管在40℃时空斑形成效率未降低，但在39℃或更高温度下，其在液体培养基中的生长明显受到抑制。
