Niimi H, Sugihara M, Yamakawa T
Biorheology. 1983;20(5):603-14. doi: 10.3233/bir-1983-20517.
The supply of oxygen to tissue from capillaries may be influenced by hemorheological factors. A hemorheological model is developed for elucidating which factors play a major role in the oxygen transport to tissue. For a capillary tissue unit, a modified cylindrical model of Krogh is used. For blood, two fluids model of red blood cells (RBCs) and plasma is used where hemoglobin release effect is included. Non-equilibrium flows as well as equilibrium flows are examined for various parameters (total flow Q or RBC velocity Vr, discharge hematocrit Hd and capillary hematocrit Hc). In equilibrium flow, Hd and Q determine the oxygen transport. In non-equilibrium flow, Hc also becomes important. Especially, hemoglobin release effect becomes significant in low Hc flow, which affects the area of lethal region in tissue.
毛细血管向组织的氧气供应可能会受到血液流变学因素的影响。为了阐明哪些因素在氧气向组织的输送中起主要作用，建立了一个血液流变学模型。对于毛细血管组织单元，使用了改良的克勒圆柱形模型。对于血液，采用红细胞和血浆的双流体模型，并考虑了血红蛋白释放效应。针对各种参数（总流量Q或红细胞速度Vr、排出血细胞比容Hd和毛细血管血细胞比容Hc）研究了非平衡流以及平衡流。在平衡流中，Hd和Q决定氧气输送。在非平衡流中，Hc也变得很重要。特别是，血红蛋白释放效应在低Hc流中变得显著，这会影响组织中致死区域的面积。
