Oja S S, Kontro P
Dev Neurosci. 1983;6(4-5):271-7. doi: 10.1159/000112354.
The kinetics and sodium-dependence of gamma-aminobutyric acid (GABA), hypotaurine and taurine uptake were analyzed in cerebral slices prepared from mice of different postnatal ages. The maximal velocities of transport (V) and the Km constants for the high-affinity uptake all decreased with age, whereas the developmental changes in the low-affinity uptake were exactly opposite. Both high- and low-affinity uptakes were sodium-dependent in all age groups. The general patterns of developmental changes were similar with all three amino acids, in keeping with the assumption of a common transport system for all of them.
分析了不同出生后年龄小鼠制备的脑片中γ-氨基丁酸（GABA）、次牛磺酸和牛磺酸摄取的动力学及钠依赖性。转运的最大速度（V）和高亲和力摄取的Km常数均随年龄降低，而低亲和力摄取的发育变化则正好相反。在所有年龄组中，高亲和力和低亲和力摄取均依赖于钠。所有三种氨基酸的发育变化总体模式相似，这与它们具有共同转运系统的假设一致。
